DNA Repair and Lung Cancer Risk

Prospective analysis of functional DNA repair assays and lung cancer risk

This study will assess lung cancer risk in relation to selected DNA repair functional assays using prospectively collected (pre-diagnostic) cryopreserved samples that have been EBV-transformed into lymphoblastoid cell lines, thus addressing the potential reverse-causation bias of previous studies. We hypothesize that higher baseline DNA damage, increased mutagen sensitivity, and lower DNA repair capacity will be associated with an elevated risk of lung cancer.